中国临床药理学与治疗学2012，Vol.17Issue(1)：10-14,5.
水飞蓟宾对D-半乳糖诱导衰老大鼠抑制糖氧化应激反应及改善学习记忆作用
Effects of silybin on inhibiting glycoxidative stress and improving the learning and memory in aging rats treated by D-galactose
傅永锦 1潘竞锵 2张小牧 1邝少松3
作者信息
- 1. 广州市中医医院,广州510130,广东
- 2. 广州市中医中药研究所,广州510130,广东
- 3. 广东省医学实验动物中心,佛山528248,广东
- 折叠
摘要
Abstract
AIM: To investigate the effects of silybin on the glycoxidative stress and the abilities of learning and memory in aging rats induced by D-galactose. METHODS: The aging rats induced by D-galactose, the abilities of learning and memory were measured by Morris water maze test in rats. To assess the glycoxidative stress, the glycosylated hemoglobin ( HbAlc) and fructosamine ( FRA), advanced glycation end products (AGEs) in plasma, the activity of aldose reductase (AR) in red blood cell (RBC) were used , the levels of malondialdehyde (MDA) and AGEs and ability of superoxide dis-mutase(SOD) in brain tissue were also acquired. RESULTS:Compared with the control group, Si-ly groups(150 mg/kg and 75 mg/kg ) obviously inhibited the activity of AR(P<0. 01) , reduced the levels of FRA, HbAlc and AGEs in rats treated by D-galactose(P<0. 01 or P<0. 05) , and the levels of MDA and AGEs were reduced while the activity of SOD in brain were elevated (P<0. 01). CONCLUSION: Silybin could improve the abilities of learning and memory in rats treated by D-galactose, and it might be related to the inhibition of glycoxidative stress and ability of AR.关键词
水飞蓟宾/衰老/D-半乳糖/糖氧化应激反应/学习记忆Key words
Silymarin/ Aging/ D-galactose/ Glycoxidative stress/Learning and memory分类
医药卫生引用本文复制引用
傅永锦,潘竞锵,张小牧,邝少松..水飞蓟宾对D-半乳糖诱导衰老大鼠抑制糖氧化应激反应及改善学习记忆作用[J].中国临床药理学与治疗学,2012,17(1):10-14,5.
