摘要
Abstract
AIM: Based on probability theory, two concrete methods for absorption kinetics were proposed in one-compartmental model. METHODS: After an extravascular administration of drug, total resident time (Th) was regarded as sum of the resident time in site of administration (Tf) and the resident time in body (Tg). Not only are Tf and Tg independent each other, Tf, Tg and Th are nonnegative, continuous random variables also. According to convolution formula and characterization of one-compartmental model ( exponential distribution ), methods of probability theory for calculating the absorption rate of drug were obtained. These methods were composed of probability method ( A approach ) and numerical deconvolution method (B approach). RESULTS: The essential conditions of method of probability theory werein accordance with that of Wagner-Nelson (W-N) formula. The accuracy of A approach was I-dentical with that of W-N formula. As long as the accurate value of first-order elimination rate constant (K) can be estimated, the accuracy of B approach was inferior to that of W-N formula. In case K value with relative error ( + 10%) was calculated, the accuracy of B approach was slightly superior to that of W-N formula. CONCLUSION; Method of probability theory can be suggested to estimate the percentage of drug absorbed and the concerned probability.关键词
药物动力学/一室模型/吸收动力学/概率论/概率/随机向量/卷积-反卷积/概率密度函数/分布函数Key words
Pharmacokinetics/ One-compartmental model/ Absorption kinetics/ Probability theory/ Random vector/ Numerical deconvolution/ Exponential distribution/ Probability density function/ Distribution function分类
医药卫生
