中国临床药理学与治疗学2012，Vol.17Issue(1)：73-77,5.
中国汉族儿童CYP3A5*3基因型与急性淋巴细胞白血病易感性的关联研究
Association of CYP3A5*3 with Acute Lymphoblastic Leukemia susceptiveness in Chinese Han children
摘要
Abstract
To investigate the association of CYP3A5* 3 with Acute Lymphoblastic Leukemia (ALL) susceptiveness in Chinese Han children.METHODS: CYP3A5 genotype was analyzed from 172 Chinese ban children,including 52ALL patients(27 female and 25 male) and 120healthy controls(80 female and 92 male).Genomic DNA was extracted from blood sample,and PCR-RFLP was used to identify the polymorphism.RESULTS: This polymorphism were matched to Hardy-Weinberg equilibrium in all group.The allelic frequency of CYP3A5* 3 was 0.721 (95％ CI: 0.549,0.893) in patients while 0.758 (95％ CI: 0.674,0.842) in healthy controls.There was no significant difference existed in CYP3A5* 3 frequencies between patients and controls (P=0.275),males and females (P=0.432) in the total population.CONCLUSION:The CYP3A5* 3 variant represents a common polymorphism in Chinese healthy children and ALL,and this polymorphism is poor association with ALL susceptiveness in children.关键词
儿童急性淋巴细胞白血病( ALL)/CYP3A5*3/遗传变异Key words
Acute Lymphoblastic Leukemia (ALL)/CYP3A5 * 3/Polymorphism分类
医药卫生引用本文复制引用
刘艳,陆晓彤,盛琦,田怀平,徐阿晶,唐跃年,卜书红,李莉霞,张健..中国汉族儿童CYP3A5*3基因型与急性淋巴细胞白血病易感性的关联研究[J].中国临床药理学与治疗学,2012,17(1):73-77,5.基金项目
Research Award Fund for out Standing Young Teachers of Shanghai （）
Project suported by the Shanghai Health Bureau,China (2009068) （2009068）
