摘要
Abstract
AIM: To evaluate the effects of two single preanesthetic doses of dexmedetomi-dine (0.5 μg/kg and 1.0 μg/kg) on bispectral index (BIS) and hemodynamic changes undergoing endotracheal intubation under induction an-esthetic with sevoflurane inhalation. METHODS; In a double-blind and random study, 45 patients scheduled for gynaecologic laparoscopy operation were divided into 3 groups (n=15 for each). Patients in Group A were anesthetizedwith inhalation of sevoflurance; Patients in Group B and Group C were anesthetized with 0. 5 μg/kg and 1. 0 μg/kg dexmedetomidine infusion before anesthetic induction with sevoflurane in oxygen by face mask. The changes in hemody-namics and BIS were observed at time points before induction (T0), after induction (T1) , and 5 min (T2 ) after intubation. Time going into sleep, time for the BIS to 60, time carrying intubation, anesthesia and operation, times carrying vital capacity breath ,and the adverse effect were also observed. RESULTS: Compared with the values at T0, the BIS, the heart rate and blood pressure were decreased remarkably at T1 (P< 0.05). At T2, the blood pressure was significantly higher than those at T0 and T1 in Group A (P<0. 05). Compared with Group A, the BIS,heart rate and blood pressure were lower in Groups B and C(P<0. 05) at T1,T2. The time going into sleep, time for the BIS to 60 and time carrying intubation were shorter in Group B and C (P<0 . 05) , especially in group C. CONCLUSION; Both dexmedetomidine 0. 5 μg/kg and 1.0 μg/kg caused sedation and significantly decreased hemodynamics and stress reaction to en-dotracheal intubation during sevoflurane anesthesia induction. Dexmedetomidine 1.0 μg/kg was better than dexmedetomidine 0. 5 μg/kg. Severe bradycardia and hypotension during anesthesia should be noticed.关键词
右旋美托咪啶/七氟醚/血流动力学/脑电双频指数Key words
Dexmedetomidine/ Sevoflurance/ Hemodynamics/ Bispectral index分类
医药卫生
