中国临床药理学杂志2012，Vol.28Issue(1)：8-12,5.
氨氯地平降压疗效与L型钙离子通道α1C亚基的基因多态性的关系
Relationship of the genetic polymorphisms of L - type calcium channel α1C gene and efficacy of amlodipine in the treatment of essential hypertension
摘要
Abstract
Objective To study association between genetic polymorphisms of L-type calcium channel alpha subunit 1C gene ( CACNAIC) and efficacy of amlodipine in the treatment of hypertension. Methods A pharmacogenetic analysis was performed on 181 Chinese individuals with essential hypertension who were treated with amlodipine based antihyper-tensive drugs. Seven SNPs ( rs1051375, rs2238032, rs7311382, rs2239050, rs2239127, rs2239128, rs2239129) in CACNA1C were chosen for genotypic analysis using direct sequencing method. Multiple linear regression was used to association analysis between genetic polymorphisms and efficacy of amlodipine. Results After adjustments of the influence of confounding factors on blood pressure, the comparison of 4th week's △SBP and △DBP over genotypes of these single nucleotide polymorphisms showed that rs2238032G/T had a more significant association with BP reduction after treatments ( △SBP: P = 0. 02; △DBP: P = 0.01). Both SBP and DBP were significantly decreased in patients with TT + GT carrier in rs2238032 G/T when compared with patients with GG carrier. And rs2239050C/G, rs7311382C/T, rs2239127C/T, rs2239128C/T, rs2239129C/T, rs1051375A/G showed a significant difference in BP reduction over genotypes respectively. Conclusion SNPs rs2238032 in CACNA1 C are associated with efficacy of amodipine in the treatment ofessential hypertension.关键词
CACNAIC基因/单核苷酸多态性/高血压/氨氯地平Key words
L - type calcium channel alpha subunit 1C gene/ single nucleotide polymorphisms/ essential hypertension/amlodipine分类
医药卫生引用本文复制引用
景林德,刘玉清,刘红,贾友宏,王文,马丽媛,黄建凤,张进虎,李一石..氨氯地平降压疗效与L型钙离子通道α1C亚基的基因多态性的关系[J].中国临床药理学杂志,2012,28(1):8-12,5.基金项目
国家"重大新药创制"科技重大专项基金资助项目(2008ZX09312-018)国家"十一五"科技支撑计划课题基金资助项目(2006BAI01A03) （2008ZX09312-018）
