中国临床药理学杂志2012，Vol.28Issue(1)：37-39,3.
羧基-D-氨基葡萄糖对食管癌裸鼠及相关基因表达的影响
Effect of 2 - [ (3 - carboxy - 1 - oxoprogyl) amino ] - 2 - deoxy - D - glucose on esophageal cancer in nude mice and expression of its relational genes
摘要
Abstract
Objective To study the influence 2 - [ (3 - carboxy -1 -oxoprogyl) amino] -2-deoxy-D -glucose glucose (COPADG) on e-sophageal carcinoma nude mice, and the expression of related genes in tumors. Methods The models of esophageal carcinoma in nude mice were established. Experimental group was divided randomly into control group, COPADG group, 5 - FU group and combination group (CF). The rate of suppression of tumor was calculated and the expression of PC-NA, caspase3, VEGF and MVD were detected by immunohistochemis-try. The apoptosis of the tumors was detected by flow cytometry. Results The rate of suppression of tumor COPADG, 5 - FU, CF groups were 54.16%, 38.78%, 73.91% respectively. The expression of VEGF, MVD in COPADG, 5 -FU, CF groups were lower than control group (P <0. 01). The expression of caspase3 in COPADG, 5 -FU, CF groups were higher than control group (P <0. 01 ). The expression of PCNA in COPADG, CF groups were lower than control and 5 - FU groups (P < 0. 01). The apoptotic cell rates in the early stage in COPADG, 5 - FU, CF groups were higher than control group (P < 0. 01 ). Conclusion COPADG can inhibit the growth of the human esophageal carcinoma in nude mice by suppressing proliferation, angiogenesis and induced apoptosis of the tumor.关键词
羧基-D-葡萄糖/食管癌/裸鼠/增殖/凋亡/血管形成Key words
2 - [ (3 - carboxy - 1 - oxoprogyl) amino ] - 2 - deoxy -D - glucose glucose/ esophageal cancer/ nude mice/ proliferation/ apoptosis/ angiogenesis分类
医药卫生引用本文复制引用
吴静,张晶,林香春,王沧海,刘红,魏南,王小波,王爱勤..羧基-D-氨基葡萄糖对食管癌裸鼠及相关基因表达的影响[J].中国临床药理学杂志,2012,28(1):37-39,3.基金项目
中国科学院西部之光基金资助项目(200524) （200524）
