中国临床药理学杂志2012，Vol.28Issue(2)：107-109,3.
头孢丙烯分散片在中国健康人体的药代动力学
Pharmacokinetics of cefprozil dispersible tablets in Chinese healthy volunteers
丁细桃 1李军伟 2邱相君 3刘涛 3胡国新2
作者信息
- 1. 温州医学院机能实验教学中心,浙江温州325035
- 2. 温州医学院药学院,浙江温州325035
- 3. 河南科技大学医学院,河南洛阳471003
- 折叠
摘要
Abstract
Objective To study the pharmacokinetics of cefprozil dis-persible tablets in healthy volunteers. Methods Ten healthy volunteers (five males and five females) received 500 mg cefprozil dispersible tablets at a single oral dose. The concentrations of cis - cefprozil and trans - cefprozil in plasma were determined simultaneously by HPLC. The pharmacokinetic parameters were calculated by DAS program. Results After a single dose of 500 mg cefprozil dispersible tablets, the pharmacokinetic parameters for cefprozil were as follows: Cmax was (9. 62 ± 1. 29) mg·L-1, Tmax was( 1.30 ±0.35) h, t1/2ke was (1.32 ±0.15) h, V was (34.40 ±5.48) L, CL was (18. 16 ±2. 96) L · h-1 ,AUC0-10 was (27. 68 ±4. 45) mg · h · L-1, AUC0-8. Was (28. 22 ±4. 70) mg · h · L-1 . Conclusion Cefprozil was fitted to a one - compartment model with first absorption.关键词
头孢丙烯/分散片/药代动力学/高效液相色谱法Key words
cefprozil/dispersible tablets/pharmacokinetics/high performance liquid chromatography分类
医药卫生引用本文复制引用
丁细桃,李军伟,邱相君,刘涛,胡国新..头孢丙烯分散片在中国健康人体的药代动力学[J].中国临床药理学杂志,2012,28(2):107-109,3.
