中国临床药理学杂志2012，Vol.28Issue(2)：110-114,5.
左西孟旦注射液在中国健康人体的药代动力学
Pharmacokinetics and safety of levosimendan injection in Chinese healthy volunteers
李晓光 1张妍 1翟所迪 1佘飞 2赵荣生 1杨丽1
作者信息
- 1. 北京大学第三医院药剂科,北京100191
- 2. 北京大学第三医院心血管内科,北京100191
- 折叠
摘要
Abstract
Objective To investigate the pharmacokinetics and safety of levosimendan injection in Chinese healthy volunteers. Methods Thirty healthy male volunteers were enrolled and divided into three groups (10 volunteers per group) and were administrated a single dose of levosimendan injection intravenously (1 mg or 2 mg or 3 mg). The concentrations of levosimendan in plasma were determined by HPLC and WinNolin was used to calculate the pharmacokinetic parameters. Results The main pharmacokinetic parameters of three test groups were as follows: Cmax were (109. 24 ±14. 52), (201. 38 ±38. 94) and (317. 65 ±45.75)ng · mL-1'respectively;^ were (11. 5 ± 2. 4) , ( 11. 5 ± 3. 4) and ( 11. 9 ± 2. 6)min, t1/2 were (0.68 ±0. 10), (0. 60 ±0. 08) and(0. 80 ±0. 08)h respectively; AUC0-t were ( 81. 38 ± 12. 64), (143. 13 ± 29. 63 ) and (289. 86 ±48. 57) μg · h · L-1 respectively. Conclusion After intravenous administration of 1,2,3 mg levosimendan injections, pharmacokinetics behaviors showed good linear relationship and safety were acceptable.关键词
左西孟旦/药代动力学/高效液相色谱法Key words
levosimendan/pharmacokinetics/HPLC分类
医药卫生引用本文复制引用
李晓光,张妍,翟所迪,佘飞,赵荣生,杨丽..左西孟旦注射液在中国健康人体的药代动力学[J].中国临床药理学杂志,2012,28(2):110-114,5.
