盐酸利托君片在中国健康人体的生物等效性OA北大核心CSCDCSTPCD
Bioequivalence of ritodrine hydrochloride tablets in Chinese healthy volunteers
目的 评价2种国产盐酸利托君片在中国健康人体的生物等效性.方法 22名健康女性受试者随机交叉单剂量口服盐酸利托君片试验药物或对照药物,各10 mg.用高效液相色谱-串联质谱法测定血浆中盐酸利托君浓度;用DAS2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的主要药代动力学参数:Cmax分别为(5.71±1.83)和(5.61±2.03)ng·mL-1;Tmax分别为(0.54±0.45)和(0.46 ±0.2…查看全部>>
Objective To evaluate the bioequivalence of two preparations of ritodrine hydrochloride tablets. Methods A single oral dose of 10 mg test and reference ritodrine hydrochloride tablets were given to 22 female healthy volunteers in a randomized crossover study. The concentrations of ritodrine hydrochloride were determined by HPLC - MS /MS method. The pharmacokinetic paramters and relative bioavailability were calculated by DAS 2. 0 software, then the bio…查看全部>>
张佳丽;吴华;潘世芬;王鹤尧
首都医科大学附属北京朝阳医院药事部,北京100020首都医科大学附属北京朝阳医院药事部,北京100020首都医科大学附属北京朝阳医院药事部,北京100020首都医科大学附属北京朝阳医院药事部,北京100020
医药卫生
盐酸利托君片生物等效性药代动力学高效液相色谱-串联质谱
ritodrine hydrochloridebioequivalencepharmacokineticsLC - MS /MS
《中国临床药理学杂志》 2012 (2)
128-130,134,4
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