中国临床药理学杂志2012，Vol.28Issue(2)：142-145,4.
DNA甲基化与药物效应的表观遗传药理学研究进展
Advances in pharmacoepigenetics:DNA methylation and drug response
摘要
Abstract
It is found that epigenetic mechanisms can affect gene expression, which provides a new explanation to the phenomenon discovered in recent years that individual differences in drug response could not be explained by genetic polymorphism. Epigenetic mechanism can modify the DNA sequences epigenetially thus change the levels of gene expression. Pharmacoepigenetics which based on the theory and technology of epigenetics and pharmacology provides a new interpretation to this phenomenon. Epigenetic mechanisms are mainly DNA methylation and his-tone modification and so on. This review described the interaction of DNA methylation and drug response.关键词
表观遗传药理学/DNA甲基化/药物效应/药物代谢Key words
pharmacoepigenetics/DNA methylation/drug response/drug metabolize分类
医药卫生引用本文复制引用
刘海燕,袁洪,黄志军,阳国平..DNA甲基化与药物效应的表观遗传药理学研究进展[J].中国临床药理学杂志,2012,28(2):142-145,4.基金项目
国家自然科学基金资助项目(30873126) （30873126）
国家"重大新药创制"科技重大专项基金资助项目(2009ZX09501-032) （2009ZX09501-032）
