中国临床医学2011，Vol.18Issue(6)：749-751,3.
季德胜蛇药对小鼠树突状细胞功能的影响
Regulatory Effects of Ji De Sheng She Yao on the Function of Dendritic Cell of Mice
摘要
Abstract
Objective: To study the regulatory effects of Ji De Sheng SheYao(JSD), a Chinese patent medicine, on the function of dendritic cell of mice. Methods: Forty-eight BALB-c mice were randomly divided into four groups (12 mice in each group): the normal control group, model group, treatment group 1 and treatment group 2. The drugs were given by intragastric gavage in every group twice every day, lasting twenty-one days. The normal control group and the model group were given the same volume of normal saline, the mice of the two treatment groups were respectively treated with drug(JSD) in corresponding dosages. From the 15th day, all experimental mice expect those of the normal control group were administered with the cyclophos-phamide (30 mg/kg,iH)for seven days. The surface molecules of dendritic cells (DCs) the function of DCs and the concentration of interleukin-12(IL-12) were measured. Results: The expression of major histocompatibility complex( MHO- II > Cdllcin the treatment group was significanT1y higher than that in model group. The abilities of DCs to stimulate T lymphocyte proliferation of mice in the treatment group were markedly higher than that of mice in model group; The contents of IL-12 in DCs's su-pernatants of treatment group were significanT1y higher than those in model group. Conclusions: JSD can increase the DCs' immune function of immune-suppressed mice.关键词
季德胜蛇药/树突状细胞/小鼠/环磷酰胺Key words
Ji De Sheng She Yao/ Dendritic cells Mouse/ Cyclophosphamide分类
医药卫生引用本文复制引用
谭晓慧,李阳,汪晓莺,周跃,沈轶瑶,汤伟..季德胜蛇药对小鼠树突状细胞功能的影响[J].中国临床医学,2011,18(6):749-751,3.基金项目
江苏省南通市科技局应用研究项目(编号:K2006009) （编号:K2006009）
