中国临床医学2011，Vol.18Issue(6)：761-763,3.
咪达唑仑与芬太尼联合应用对小鼠学习记忆的影响
Effects of Combination of Midazolam and Fentanyl on the Learning and Memory in Mice
摘要
Abstract
Objective:To investigate the impacts of combination of midazolam and fentanyl on learning and memory in mice. Methods; A total of 80 mice were divided into either steβ-through test group or steβ-down test group, each group was thereby divided into 4 subgroups (n= 10): Control group (Group C), midazolam group (Group M), fentanyl group (Group F) and combination of midazolam and fentanyl group (Group M+ F). Latency and error times in each group were observed by steβ-through test and steβ-down test to evaluate the effects of medicines on learning and memory in mice. Results: Twenty-four hours after training, in steβ-through test, compared with Group F or Group M, the latency of Group M+ F decreased (P< 0. 05) but the error times did not change (P<0.05); in steβ-down test, the latency of Group M + F decreased (P<0. 05) and the error times increased (P<0.05). Forty-eight after training, there were no significant differences in the latency and error times in each group (P>0. 05). Conclusions: Combination of midazolam and fentanyl can impair the learning and memory function during the medicines acting period, but the dysfunction disappears after 24h. It implies that the medicines cause no persistent dysfunction in learning and memory.关键词
咪达唑仑/芬太尼/学习记忆/避暗实验/跳台实验Key words
Midazolam/ Fentanyl/ Learning and memory/ Step-through test/ Step-down test分类
医药卫生引用本文复制引用
晏明,王玲,韩孟和,范洁,李佳芹,戴雷,丁秋,马涛,刘金东..咪达唑仑与芬太尼联合应用对小鼠学习记忆的影响[J].中国临床医学,2011,18(6):761-763,3.基金项目
2010年高等学校大学生实践创新训练计划项目(编号:2010798) （编号:2010798）
浙江省宁波市医学科技计划项目(编号:2007014) （编号:2007014）
