中国临床医学2011，Vol.18Issue(6)：785-787,3.
冠心病介入治疗前后血清白细胞介素18、可溶性CD40L和超敏C反应蛋白变化与早期并发症的关系
Investigation of the Effects of PCI on Serum IL-18, sCD40L and hs-CRP Levels in Patients with Coronary Artery Disease and the Relationship between Early Complications
晋群 1秦永文 2李晓燕 1许琳 1张洪明1
作者信息
- 1. 济南军区总医院心内科,山东济南 250031
- 2. 第二军医大学附属长海医院心内科,上海200433
- 折叠
摘要
Abstract
Objective:To explore the changes of serum levels of IL-18, sCED40L and hsCRP in coronary artery disease after PCI and to investigate the prognostic value of IL-18 and hsCRP for early complications after PCI. Methods: A total of 85 patients with ACS which including 44 patients with UA and 41 patients with AMI were enrolled. All patients were treated by PCI. The pre-αnd pro-procedural levels of serum IL-18 and hsCRP were tested to investigate the changes of serum levels of IL-18, sCD40L and hsCRP and the prognostic value for early complications after PCI. Results: Incidence of the early complications was 9. 4 %(8/85) in the whole population, incidence in AMI 14. 6 %(6/41) was higher than that in UA 4. 5 %(2/44) (P<0. 05). The levels of serum IL-18, sCD40L and hsCRP of patients of early complications before PCI was higher than those without early complications before PCI (P<0. 05). The increase of serum IL-18, sCEMOL and hsCRP of patients of early complications after PCI was higher than those without early complications after PCI (P<0.05). Conclusions: The earlier inflammation reaction in coronary artery may be triggered and aggravated by PCI. The occurrence of early complications after PCI may concerned with inflammatory responses. IL-18, sCD40L and hsCRP may provide more powerful predictors of early complications after PCI.关键词
冠心痛/白细胞介素18/CD40L/超敏C反应蛋白/经皮冠状动脉介入治疗/早期并发症Key words
Coronary heart disease/ IL-18/ CD40L/ hsCRP/ Percutaneous coronary intervention/ Early complications分类
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晋群,秦永文,李晓燕,许琳,张洪明..冠心病介入治疗前后血清白细胞介素18、可溶性CD40L和超敏C反应蛋白变化与早期并发症的关系[J].中国临床医学,2011,18(6):785-787,3.
