中国临床医学2011，Vol.18Issue(6)：818-820,3.
中药加味一贯煎提高原发性肝癌晚期患者生存率的临床研究
Clinical Study on Jiawei Yiguanjian for Improvement of the Survival Rate in Advanced Hepatocellular Carcinoma Patients
摘要
Abstract
Objective:To evaluate the effect of Jiawei Yiguanjian on improving survival time and life quality in advanced hepato-cellular carcinoma( HCC) patients. Methods: A total of 100 patients (males 84,females 16) with advanced HCC of Zhongshan Hospital,Fudan university were randomized into two groups: The TCM therapy group and the control group. The control group received ordinary therapy while the treatment group received extra Jiawei Yiguanjian. The half-year survival rate,median survival time,quality of life score (Karnofsky),score of Eastern Cooperative Oncology Group(ECOG) and score of traditionnal chi-nese medical syndrome were compared between the two groups. Results: The half year survival rate with TCM therapy was 35. 80% and the median survival time was 114 days, and 21. 21% ,71days of the control group respectively. The difference was significant between the two groups(F<0. 05). There were much apparent differences in score of traditionnal Chinese medical syndrome, quality of life score (Karnofsky) and score of ECOG (P<0. 05). The TCM therapy group was better than control group at improving symptom,life quality and physical strength. Meanwhile, the mortality risk of advanced HCC patients was related to ECOG score and Child-Pugh score. The mortality increased significanT1y with the rise of the ECOG score and Child-Pugh score, the mortality rate increased 1. 8 times by adding one ECOG score and 1. 24 times by adding one Child-Pugh score. Conclusions; Using Jiawei Yiguanjian can increase the half-year survival rate and median survival time, improve the life quality and physical status of advanced HCC patients and reduce the score of traditionnal Chinese medical syndrome.关键词
晚期原发性肝癌/中药治疗/中位生存期/半年生存率Key words
Advanced hepatocellular carcinoma/ TCM therapy/ Median survival time/ Half-year survival rate.分类
医药卫生引用本文复制引用
杨云柯,仇冬则,王国骅,顾喜喜,范越,唐辰龙..中药加味一贯煎提高原发性肝癌晚期患者生存率的临床研究[J].中国临床医学,2011,18(6):818-820,3.基金项目
上海市卫生局科研项目资助(编号:2006L021A) （编号:2006L021A）
