中国临床医学2012，Vol.19Issue(1)：11-13,3.
CD90和CD44在人肝癌组织中的表达及临床意义
Expression and Clinical Significance of CD90 and CD44 in Human Hepatocarcinoma Tissues
摘要
Abstract
Objective:To study the expression of CD90 and CD44 in human hcpatocciiuar carcinoma (HCC) tissues, and to explore the relationship between their expression and recurrence of HCC. Methods: We collected tissue samples of 20 HCC patients, who had been followed up for more than one year, including 10 cases with recurrence and 10 cases without recurrence. Specimens were embedded in paraffin, and then 3 pieces were cut from each specimen in the thickness of ljLtm. The first piece was routinely HE stained for pathological diagnosis. The other two consecutive pieces were used to detect CD90 and CD44 by immunohisto-chemistry. The expression of CD90 and CD44 in recurrence group and recurrence-free group was compared. Results: The expression of CD90 and CD44 in human HCC tissues was from 0. 13% to 4. 10%. The expression of CD90 and CD44 had a relationship with HCC recurrence and prognosis. The expression of CD90 in the recurrent group was significantly higher than that in the recurrent-free group. Most of CD90 or CD44 positive cells were closed to vessels in recurrence group. Conclusions: Liver cancer stem cells exist in HCC tumor tissues with significant heterogeneity, and they express a variety of cancer stem cell markers such as CD90 and CD44. The expression of liver cancer stem cell markers is correlated with recurrence of HCC关键词
肝癌干细胞/表面标志物/CD90/CD44/复发/预后Key words
Liver cancer stem cells/ Biomarkcr/ CD90/ CD44/ Recurrence/ Prognosis分类
医药卫生引用本文复制引用
刘黎黎,符达,朱玉珍,吴盛迪,马雨水,王吉耀,沈锡中..CD90和CD44在人肝癌组织中的表达及临床意义[J].中国临床医学,2012,19(1):11-13,3.基金项目
国家重大科技专项(编号:2009ZXl0004-301) （编号:2009ZXl0004-301）
2011年复旦大学附属中山医院青年基金 （）
