中国临床医学2012，Vol.19Issue(1)：19-21,3.
社区单用或联合应用支气管扩张剂长期治疗稳定期慢性阻塞性肺疾病的临床研究
Long-term Treatment of Stable COPD with Single or Associated Bronchodilators in Community
摘要
Abstract
Objective:To observe the clinical curative effect and safety of single or associated ipratropium bromide aerosol and Thco-Dur in long-term treatment of stable chronic obstructive pulmonary discasc(COPD) in community and to evaluate amelioration of exercise tolerance and life quality of COPD patients. Methods: A total of 185 patients with stable COPD were randomly divided into three group: ipratropium bromide group, thcocin group and associated group. Ipratropium bromide group breathe in aerosol of ipratropium bromide, thcocin group take Thco-Dur orally, the associated group was treated with both ipratropium bromide and Thco-Dur. All participants had lung function test and 6 minute walk test (6MWT) before treatment and at 3 months, 6 months after treatment. March score of dyspnea and quality of life, acute episode frequency and adverse reaction were recorded during treatment. Results; After 6 months treatment, in all of the three groups, lung function was obviously improved , 6MWD/prcdiction (%) increased obviously, dyspnea score and quality of life score was obviously improved, Indicators of the three groups have significant difference before and after treatment (P<C0. 01). During six months the acute episode frequency was obviously decreased compared with before treatment in all of the three groups, and the difference was significant (P^O. 05), the ipratropium bromide group and the associated group being more drastically. The incidence of adverse reactions were few in all of the three groups. Conclusions: Ipratropium bromide aerosol, Thco-Dur, single or associated in long-term treatment of moderate or severe stable COPD, all can improve lung function and clinical symptoms of the patients, increase exercise tolerance, improve quality of life, reduce acute episodes, while the adverse reactions is rare. In particular, ipratropium bromide has exact effect, and was easy to use and more secure, and thus make it a better choice in long-term treatment of stable COPD.关键词
社区/稳定期/氨茶碱/异丙托溴铵/慢性阻塞性肺疾病Key words
Community/ Stable/ Aminofilnc/ Ipratropium bromide/ Chronic obstructive pulmonary disease分类
医药卫生引用本文复制引用
马云霞,苗玉兰,马正义,沈迁,李瑞,马俏玲..社区单用或联合应用支气管扩张剂长期治疗稳定期慢性阻塞性肺疾病的临床研究[J].中国临床医学,2012,19(1):19-21,3.基金项目
中华医学会CRD专项资金资助课题(编号:07010190027) （编号:07010190027）
