中国美容医学2012，Vol.21Issue(4)：587-589,3.
乙酰水杨酸在UVB诱导黑素细胞树突形态相关分子Rac1和RhoA表达中的作用
Effect of ASA on the expression of the dendrites regulating factors Rac1 and RhoA in melanocytes induced by UVB irradiation
惠坤 1简强 1薛柯 1朱东宁 1安庆 1李承新1
作者信息
- 1. 第四军医大学西京医院全军皮肤病研究所,陕西,西安,710032
- 折叠
摘要
Abstract
Objective To investigate the effect of acetylsalicylic acid (ASA )on the expression of the dendrites regulating factors Rac1 and RhoA in melanocytes induced by UVB Irradiation. Methods Melanocytes cultured in plates were divided into 3 groups, control group, 100mJ UVB irradiation group and UVB irradiation plus ASA treatment group, respectively The mRNA expression of Rac1 and RhoA was analysed with real time RT-PCR, and protein expression was assayed by western blotting. Results Compared with control group, UVB irradiation enhanced the protein and mRNA expression of Rac1,while decreased the expression of RhoA. However, ASA treatment could inhibit the influence of UVB irradiation on the Rac1 and RhoA. The protein and mRNA expression of Rac1was decreased obviously and expression of RhoA was enhanced after treatment with ASA. Conclusions UVB irradiation can increase the expression of Rac1 and decrease the expression of RhoA in melanocytes and ASA can suppress these change induced by UVB irradiation.关键词
黑素细胞/UVB照射/ASA/树突/Rac1/RhoAKey words
melanocyte/UVB irradiation/ASA/Rad /RhoA/dendrites分类
生物科学引用本文复制引用
惠坤,简强,薛柯,朱东宁,安庆,李承新..乙酰水杨酸在UVB诱导黑素细胞树突形态相关分子Rac1和RhoA表达中的作用[J].中国美容医学,2012,21(4):587-589,3.
