中国美容医学2012，Vol.21Issue(4)：599-601,3.
玉竹对UVB诱导HaCaT细胞损伤的保护作用
Protective effects of yuzhu on hacat cells damaged by ultraviolet B
摘要
Abstract
Objective To investigate the protective effect of water-extract solution of Yuzhu on HaCaT cells injured by irradiation of ultraviolet B and its possible mechanisms. Methods Cell photoaging model was established by irradiating HaCaT cells with UVB (64mJ·cm-2). HaCaT cells were treated with different concentration water-extract solution of Yuzhu. The activity of superoxide dismutase (SOD) and glutathione peroxidase(GSH-Px),the content of malondialdehyde (MDA) were detected by biochemical assay, the secretion levels of TNF-α and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results The proliferation activity of HaCaT cells descended with the UVB irradiation, theactivities of SOD and GSH-Px decreased, when the content of MDA, TNF-α, IL-6, were ascensive (P<0.01). But under the intervention at middle concentration (100pg·m|-1) and high concentration (200pg·ml-1) of water-extract solution of Yuzhu, the above changes induced by UVB irradiation were inhibited (P<0.05 or P<0.01). Conclusion The water-extract solution of Yuzhu might inhibit the proliferation decreasing which induced by UVB. And its mechanism may have relationship with the ability of strengthening antioxidation, decreasing oxygen radicals and decreasing the secretions of proinflammatory cytokines.关键词
玉竹/UVB/HaCaT细胞/保护作用Key words
YuzhuUVB/HaCaT cells/protective effects分类
生物科学引用本文复制引用
王业秋,陈巧云,张宁,井丽巍,祁永华..玉竹对UVB诱导HaCaT细胞损伤的保护作用[J].中国美容医学,2012,21(4):599-601,3.基金项目
黑龙江省科学基金(QC2010085) （QC2010085）
