中国脑血管病杂志2011，Vol.8Issue(12)：632-636,5.DOI:10.3969/j.issn.1672-5921.2011.12.004
烟雾病合并甲状腺功能亢进症患者的临床分析
Clinical analysis of patients with moyamoya disease complicating hyperthyroidism
摘要
Abstract
Objective To investigate the clinical features, pathogenesis and the effect of surgical and medical treatment of patients with moyamoya disease complicating hyperthyroidism. Methods The clinical data of 11 patients with moyamoya disease complicating hyperthyroidism were analyzed retrospec-tively, 10 of them were diagnosed by digital substraction angiography ( DSA), and 1 was diagnosed by magnetic resonance angiography. All the patients met the diagnostic criteria of hyperthyroidism. After con-trolling hyperthyroidism, 8 patients underwent encephalo-duro-arterio-synangiosis, the other 3 were only given drugs to control hyperthyroidism. Results ①Ten of the 11 patients (8 females) showed thyroid dysfunction, with increased 3,5,3-triiodothyronine (T3) and thyroxine (T4), and the decreased thyroid stimulating hormone (TSH). ②Nine of the 11 patients showed cerebral infarction, 1 showed intraventricu-lar hemorrhage and 1 did not found any abnormality in imaging findings. Ten patients had bilateral lesions and 1 had unilateral lesions. ③Eleven patients were followed-up for 11-102 months. Except 1 patient left mental decline and slow reaction, the symptoms of others were relieved or disappeared after the treatment. After encephalo-duro-arterio-synangiosis, 8 patients did not have any surgical complications, 6 of them con-ducted postoperative angiography (10-26 months) and all showed a great deal of compensatory blood supply from extracranial to intracranial arteries. Conclusion Moyamoya disease complicating hyperthyroidism is mostly occured in female patients and their clinical symptoms are mainly cerebral infarction. The pathogenesis of moyamoya disease complicating hyperthyroidism remains unclear. It may be associated with a variety of ge-netic and immune factors. After controlling hyperthyroidism, surgical treatment can establish effective collat-eral circulation and reduce the risk of recurrence of stroke.关键词
脑底异常血管网病/甲状腺功能亢进症/脑梗死/烟雾病综合征Key words
Moyamoya disease/ Hyperthyroidism/ Brain infarction/ Moyamoya syndrome引用本文复制引用
李德生,刘鹏,暴向阳,杨伟中,张正善,咸鹏,杨日淼,段炼..烟雾病合并甲状腺功能亢进症患者的临床分析[J].中国脑血管病杂志,2011,8(12):632-636,5.基金项目
国家自然科学基金资助项目(81171083) （81171083）
首都医学发展科研基金重点项目(2007-2028) （2007-2028）
