中国脑血管病杂志2012，Vol.9Issue(1)：27-31,5.DOI:10.3969/j.issr.1672-5921.2012.01.006
缺血性卒中急性期患者血清半胱氨酸蛋白酶抑制剂C水平的变化
Clinical significance of serum cystatin C in patients with acute ischemic stroke
叶明 1李淮玉 1朱余友 1王国平 1丁小灵 1马筱玲2
作者信息
- 1. 230001合肥,安徽医科大学附属省立医院神经内科
- 2. 230001合肥,安徽医科大学附属省立医院检验科
- 折叠
摘要
Abstract
Objective To investigate the correlation and clinical significance of serum cystatin C ( Cys-C) level and ischemic stroke. Methods A total of 147 patients with acute ischemic stroke were recruited. They were divided into small, medium and large sub-groups according to the infarct volume of the brain. They were also divided into high-risk group (the National Institute of Health Stroke Scale > 8 ) and low-risk group ( NIHSS ≤ 8 ) according to the scores of NIHSS. Sixty patients without stroke were selected as a control group. A particle enhanced immunoturbidimetric assay was used to detect the serum Cystain C levels, investigate the relationship between Cystain C level and ischemic stroke and analyze the correlation between Cystain C level. Results ①The serum Cystain C level 1.20 ±0.40mg/L in the ischemic stroke group was significantly higher than 0. 86 ±0.23 mg/L in the control group. The difference was statistically significant ( P < 0.05 ). With the increase in infarct volume, the serum Cystain C level also increased. The difference was statistically significant (P <0. 05). ②The serum Cystain C level 1. 33 ±0. 52 mg/L in a stroke recurrence group was higher than 1. 12 ±0. 28 mg/L in a initial stroke group. The difference wasstatistically significant (P <0.01). ③The serum Cystain C level has no correlation with the NIHSS score, but the serum Cystain C level 1. 37 ±0. 68 mg/L in the high risk group was higher than 1. 15 ±0.27 in the low risk group. The difference was statistically significant ( P < 0. 01). ④The serum Cystain C level was positively correlated with homocysteine ( Hey) (r = 0. 189, P = 0. 022) and very low density lipoprotein cholesterol (VLADL-C) (r =0.255, P =0.002) , however, it was negatively correlated with high density lipoprotein cholesterol (HDL-C) (r= -0. 173, P = 0. 036). ⑤Multivariate logistic regression analysis showed that the serum Cystain C was a risk factor for ischemic stroke ( OR = 2. 646, 95% CI 1. 621 - 4.317, P <0. 01). Conclusion The increased serum Cystain C level is an independent risk factor for ischemic stroke, it is associated with the lesion size and the severity of cerebral infarction. The serum level may be used as a reference indicator for the occurrence and development of cerebral infarction and disease surveillance.关键词
卒中/脑缺血/半胱氨酸蛋白酶抑制剂/临床研究Key words
Stroke/Bain ischemia/Cystaine proteinase inhibitors/Clinical study引用本文复制引用
叶明,李淮玉,朱余友,王国平,丁小灵,马筱玲..缺血性卒中急性期患者血清半胱氨酸蛋白酶抑制剂C水平的变化[J].中国脑血管病杂志,2012,9(1):27-31,5.
