中国农业科技导报2011，Vol.13Issue(6)：66-71,6.DOI:10.3969/j.issn.1008-0864.2011.06.11
立体分子伴侣-脂肪酶特异折叠酶
Steric Chaperone-lipase Specific Foldase
摘要
Abstract
Lipases represent the most important class of enzymes used in industry. The enzymes originated from Pseudomonas and Burkholdeiia species are wildly used. But a huge energetic barrier traps kinetically disable Upases in folding state to fold rightly. Research found that these enzymes were usually encoded in an operon together with a second gene, which coded for a lipase-specific-foldase, Lif. It is necessary for obtaining enzymatically active lipase. Lifs are so-called steric chaperones, which exert their physiological function by lowering energetic barriers when folding their cognate Upases, thereby providing essential steric information needed for folding Upases into their enzymatically active conformation. In this review, we elaborated the discovery, classification, mechanism, and perspective for application of lipase specificfoldase.关键词
细菌脂肪酶/脂肪酶特异折叠酶/立体分子伴侣/蛋白折叠Key words
bacteria lipase/lipase specific foldase/steric chaperone/protein folding分类
生物科学引用本文复制引用
郑小梅,初晓宇,伍宁丰,范云六..立体分子伴侣-脂肪酶特异折叠酶[J].中国农业科技导报,2011,13(6):66-71,6.基金项目
国家自然科学基金项目(30900839)资助. （30900839）
