中国全科医学2011，Vol.14Issue(30)：3428-3430,3434,4.
蛛网膜下腔出血患者脑脊液和血液乳酸、糖水平及其比值动态变化的临床意义
Levels of Lactate and Glucose in the Cerebrospinal Fluid and Blood of Subarachnoid Hemorrhage Patients,Dynamic Changes of
摘要
Abstract
Objective To explore the dynamic changes of lactate, glucose levels and lactate - to - glucose ratio ( L/ G ? R ) in the cerebrospinal fluid ( Csf) and blood of subarachnoid hemorrhage ( SAH ) patients and to analyze the correlations with cerebral vasospasm ( CVS ) secondary to SAH. Methods Twelve hospitalized patients with back or leg pain were enrolled as controls while 47 SAH patients admitted within 24 hours after onset were enrolled and classified according to the presence of neurological symptoms as the CVS group ( n = 19 ) and the nCVS group ( n =28 ). Csf and blood levels of lactate, glucose and transcranial doppler ( TCD ) results on day 1, 3, 7, 10 and 14 in each group were analyzed, with L/G · R of Csf and blood were calculated. Results Nineteen patients developed CVS, 4 on day 1 ~ 2 after SAH, 13 on day 3 ~ 7, 2 on day 8 ~ 10. The levels of Csf - Lac, blood - Glu, L/G · R and VmMCA increased significantly in the SAH groups at different time points compared with the control group ( P ＜ 0. 05 =; the above indicators were statistically different among the CVS, nCVS and control group ( P ＜0. 01 =; the differences between the CVS and the nCVS group were statistically significant ( P ＜0. 05 =, while levels of Csf glucose and blood lactate were not significantly different among the three groups ( P ＞ 0. 05 ). Conclusion Csf lactate, blood glucose and the corresponding L/G · R of Csf and blood rise during CVS and fall back to normal on the 14th day after SAH. Biochemical indices of Csf and blood are of great value in predicting the onset of CVS secondary to SAH.关键词
蛛网膜下腔出血/血管痉挛/颅内/脑脊液/血液/乳酸/糖Key words
Subarachnoid hemorrhage/ Vasospasm, intracranial/ Cerebrospinal fluid/ Blood/ Lactic acid/ Glucose分类
医药卫生引用本文复制引用
杨前进,陈荣植,王丹..蛛网膜下腔出血患者脑脊液和血液乳酸、糖水平及其比值动态变化的临床意义[J].中国全科医学,2011,14(30):3428-3430,3434,4.基金项目
广东省江门市科技局科技计划项目(江科[2009]74号-5) （江科[2009]74号-5）
