中国全科医学2011，Vol.14Issue(30)：3442-3444,3.
Akt/mTOR信号通路蛋白在胃癌组织中的表达及其临床意义
The Expression and Clinical Significance of Akt/mTOR Signal Pathway Proteins in Gastric Carcinoma
晏淼 1朱正秋 2卞保祥 1郑义同1
作者信息
- 1. 222000江苏省连云港市,徐州医学院附属连云港医院,连云港市第一人民医院肿瘤科
- 2. 徐州医学院附属医院肿瘤科
- 折叠
摘要
Abstract
Objective This study aims to examine the expression of active forms of the Akt/mTOR signal pathway proteins , p - Akt and p - mTOR, in gastric carcinoma and to analyze the correlations with clinical pathology characteristics. Methods The expression of p - Akt and p - mTOR was determined in 93 specimens of gastric carcinomas and 40 of control tissues by immunohistochemistry. The correlations between expression levels and clinical pathology features of gastric carcinoma were analyzed. Results The positive rates of p - Akt and p - mTOR in gastric carcinomas were 54. 8% (51 cases ) and 57. 0% ( 53 cases ) respectively, both significantly higher than in the control tissues ( P ＜0. 01 ). The positive rates of the two proteins were also significantly different among cases of different depth of invasion, degrees of differentiation, lymph node metastasis status and clinical stages ( P ＜0. 05 ); but were not significantly different among cases of different ages and genders ( P ＞0. 05 ). The expression of p - Akt and p - mTOR was positively correlated in gastric carcinoma tissues ( r =0. 327, P ＜0. 01 ). Conclusion The expression of Akt/mTOR signal pathway proteins in gastric carcinoma is positively correlated with tumor progression, the detection of which shed light on the prediction of prognosis. Still, these proteins might serve as new molecular markers and targets for treatment.关键词
胃肿瘤/Akt/哺乳动物雷帕霉素靶蛋白/信号传导/肿瘤转移Key words
Stomach neoplasms/ Akt/ Mammalian target of rapamycin/ Signal transduction/ Neoplasm metastasis分类
医药卫生引用本文复制引用
晏淼,朱正秋,卞保祥,郑义同..Akt/mTOR信号通路蛋白在胃癌组织中的表达及其临床意义[J].中国全科医学,2011,14(30):3442-3444,3.
