中国全科医学2011，Vol.14Issue(30)：3487-3490,4.
进展期胃癌术后早期腹腔灌注化疗对患者生存期和复发率影响的Meta分析
Impact of Early Postoperative Intraperitoneal Chemotherapy on Clinical Survival and Recurrence Rates in Treatment of Advanced Gastric Cancer:A Meta Analysis
摘要
Abstract
Objective To evaluate the effects of early postoperative intraperitoneal chemotherapy in the treatment of advanced gastric cancer. Methods We searched Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database , China Academic Journal, Chinese Science and Technology Journal Full - text database for literatures published between the establishment of these databases and September 2010. We also traced related references and experts in this field, as well as communicated with other authors to obtain certain information that had not been found. Randomized controlled trials of early postoperative intraperitoneal chemotherapy in treatment of gastric cancer were included. We evaluated the quality of these studies and analyzed the data by Cochrane Collaboration's RevMan 5. 0 software. Results Nine RCTs ( 1171 patients altogether ) were included. Meta - analysis results showed that compared with intravenous chemotherapy alone, early postoperative intraperitoneal chemotherapy improved 1,2,3 and 5 - year survival rates and reduced 2 and 3 - year relapse rates and intra - abdominal recurrence. Meanwhile, early postoperative intraperitoneal chemotherapy reduced the incidence of nausea and vomiting and displayed a protective effect on liver function and renal function. Conclusion Compared with intravenous chemotherapy, early postoperative intraperitoneal chemotherapy improves survival rate and reduces both recurrence rate and toxic side effects in advanced gastric cancer patients.关键词
进展期胃癌/腹腔化疗/Meta分析Key words
Advanced gastric cancer/ Intraperitoneal chemotherapy/ Meta - analysis分类
医药卫生引用本文复制引用
张元莉,王权,王灿,何曦冉,王世言,关泉林..进展期胃癌术后早期腹腔灌注化疗对患者生存期和复发率影响的Meta分析[J].中国全科医学,2011,14(30):3487-3490,4.基金项目
兰州大学2010年本科生创新创业计划项目 （）
