中国全科医学2012，Vol.15Issue(5)：527-528,532,3.
血管性血友病因子在老年2型糖尿病中的变化及其与冠心病关系的研究
Changes of von Willebrand Factor in Senile Patients with Type 2 Diabetes Mellitus and Its Relationship with Coronary Artery Disease
陈陵霞 1苗懿德 1孟春英 1韩虹2
作者信息
- 1. 100044,北京市,北京大学人民医院老年科
- 2. 100044,北京市,北京大学人民医院检验科
- 折叠
摘要
Abstract
Objective To investigate the changes of von Willebrand factor ( vWF ) in senile patients with type 2 diabetes mellitus ( T2DM ) and its relationship with coronary artery disease ( CAD ). Methods Totally 115 senile T2DM patients ( T2DM group ) and 122 senile patients without diabetes ( control group ) were included in this study. The level of serum vWF, fasting glucose, HbA1c, cholesterol, low - density lipoprotein, high - density lipoprotein, triglycerides, uric acid, fibrino-gen, and D - dimer were measured. Creatinine ratio of urinary albumin was measured in a first - morning - void urine sample. Clinical data and some biochemical items were compared between the T2DM group and control group and between those with or without CAD. The correlation of these items was analyzed simultaneously. Results Compared with the control group, the T2DM group had significantly higher vWF level [ ( 189. 8 ± 56. 2 )% vs ( 140. 3 ± 35. 6 )% , P < 0. 01 ]. Inside the T2DM group, vWF in patients with coronary artery disease ( CAD ) was significantly higher than in those without CAD [ ( 197. 3 ± 52. 5 )% vs ( 172. 8 ±54. 5 )% , P <0. 05 ]. No correlation was observed between vWF and other clinical items. Conclusion Senile T2DM patients tend to have higher vWF levels, which shows certain association with CAD.关键词
糖尿病,2型/血管性血友病因子/冠心病Key words
Diabetes mellitus, type 2/ von Willebrand factor/ Coronary disease分类
医药卫生引用本文复制引用
陈陵霞,苗懿德,孟春英,韩虹..血管性血友病因子在老年2型糖尿病中的变化及其与冠心病关系的研究[J].中国全科医学,2012,15(5):527-528,532,3.
