中国全科医学2012，Vol.15Issue(5)：538-540,3.
小剂量来氟米特治疗类风湿关节炎的长期疗效观察
Efficiency of Low-Dose Leflunomide in Treating Active Rheumatoid Arthritis: An Eighteen-Month Trial
摘要
Abstract
Objective To determine the long term clinical efficiency of low - dose leflunomide in treating rheumatoid arthritis. Methods Twenty - eight patients with active rheumatoid arthritis were randomly divided into therapy group ( thirteen), which was administered low dose leflunomide ( omitting loading dose, maintenance dose 10 mg/day ) and control group ( twelve ), which was administered sulphasalazine ( 1. 5 ~2. 0 g/d ). The treatment lasted for eighteen months. The indexes observed : the primary end - points including the numbers of tender and swollen joints and general assessments of physicians and patients , secondary end - points including VAS, morning stiffness, HAQ, CRP level and the efficiency evaluation indexes judged by the Institute of Rheumatology of the United States ( ACR20 and ACR50 ). Results After eighteen months' treatment, all the primary end - points in the therapy group got better improvements than that in the control group ( P <0. 05 ). In addition, all the secondary end - points in the therapy group also got better improvements than that in the control group ( P < 0. 05 ). 76. 9% of the cases in the therapy group and 75. 0% in the control group reached the standard of ACR20, and the difference was not significant ( P >0. 05 ). 61. 5% of the cases in the therapy group and 41. 7% of the cases in the control group reached the standard of ACR50, and the difference was significant ( P <0. 05 ). In the process of treatment, the patients in the therapy had slight gastrointestinal discomfort, two cases' blood pressure began to rise, two cases' liver enzymes began to rise and two cases dropped out; there was only one cases in the control group dropped out. Conclusion Comparing with sulphasalazine, long term of low - dose leflunomide in treating active RA can bring about sure curative effect and the patients can have good endurance of medicine.关键词
关节炎,类风湿/来氟米特/小剂量/治疗结果Key words
Arthritis,rheumatoid/ Leflunomide/ Low - dose/ Treatment outcome分类
医药卫生引用本文复制引用
王军,祖比亚,林德帅,杨俊生,覃学勇,廖明..小剂量来氟米特治疗类风湿关节炎的长期疗效观察[J].中国全科医学,2012,15(5):538-540,3.基金项目
广西卫生厅自筹经费课题(Z2010135) （Z2010135）
