中国全科医学2012，Vol.15Issue(6)：674-676,3.
肠道去污剂经不同途径给药对肝硬化患者肠黏膜通透性及血清内毒素水平的影响
Influence of Intestinal Detergent by Different Administration on Bowel Mucosa Permeability and Serum Endotoxin Level in Patients with Liver Cirrhosis
摘要
Abstract
Objective To compare the influences and differences of intestinal detergent by administrations of oral and retention enema on bowel mucosa permeability and serum endotoxin level in patients with liver cirrhosis to provide clinical evidence for the treatment of liver cirrhosis. Methods 78 patients with liver cirrhosis were randomly divided into oral group and retention enema group according to different administration methods. Despite routine treatment, oral group was given suspension of intestinal detergent and 0. 9% sodium chloride injection, while retention enema group was given detergent by catheter through a-nal, and the two groups were both treated for 14 days. Child - Pugh score was compared between the two groups before and after treatment. The bowel mucosa permeability [ indicated by urine lactulose/mannitol discharge rate ( L/M ) ] and serum endotoxin level were measured and the correlation between the two was analyzed. Results The differences of L/M value, serum endotoxin level and Child - Pugh score between the two groups were not statistically significant before treatment ( P > 0. 05 ). While after treatment, the L/M value, serum endotoxin level and Child - Pugh score were significantly lower in retention enema group than in oral group ( P < 0. 05 ). The bowel mucosa permeability was positively correlated with serum endotoxin level ( r = 0. 8287, P < 0. 05 ). Conclusion Retention enema of intestinal detergent can protect and improve the protective function of the intestine of patients with liver cirrhosis, and it can also decrease the serum endotoxin level, benefiting the recovery of the liver function in liver cirrhosis patients.关键词
肝硬化/肠道去污剂/肠黏膜/通透性/内毒素类/投药途径Key words
Liver cirrhosis/ Intestinal detergent/ Intestinal mucous/ Permeability/ Endotoxins/ Drug administration routes分类
医药卫生引用本文复制引用
覃慧敏..肠道去污剂经不同途径给药对肝硬化患者肠黏膜通透性及血清内毒素水平的影响[J].中国全科医学,2012,15(6):674-676,3.基金项目
宜昌市科技局立项(A06402) （A06402）
