中国人兽共患病学报2012，Vol.28Issue(1)：6-9,13,5.
2010年福建省肠道病毒71型分离株的基因型特征研究
Genotyping of enterovirus 71 strains isolated in Fujian Province,2010
摘要
Abstract
Enterovirus type 71 (EV71) is a common cause of pediatric hand, foot and mouth disease (HFMD). The genetic background of current EV71 isolates was investigated, and the distribution and transmission characteristics of EV71 strains in Fujian Province were analysed in this study. The complete VP1 sequences of 50 EV71 strains, isolating from specimens of 50 HFMD patients in Fujian in 2010, were sequenced, homologically compared and phylogenetically analysed. Sequences analysis revealed that the full-length VP1 region of 50 Fujian EV71 strains was 891bp. Within 50 Fujian EV71 isolates, the nucleotide and amino acid identity were 95. 4%-100% and 97. 3%-100% respectively, sharing high homology with Fuyang 17. 08-2 both in nucleotide and amino acid sequences, with the identity of 97. L%-99. 3% in nucleotides and 98. 7%-100% in amino acids, respectively. Phylogenetic analysis based on complete VP1 sequence also indicated that 50 Fujian EV71 strains had a close genetic relationship with Fuyang 17. 08-2, which also belonged to the same subgenotype, C4a. Therefore, no obvious antigenic drift or mutation was observed. However, as closely related subgenotype C4a EV71 have multiple transmission chains in Fujian Province and in each prefecture, extensive surveillance and analysis are required.关键词
肠道病毒71型/VP1区/基因型特征Key words
Enterovirus 71/VP1 genome/gene characterization分类
医药卫生引用本文复制引用
陈炜,郑奎城,严延生,周朝晖,张拥军,翁育伟,谢剑锋,吴冰珊,王金章,黄萌,沈晓娜..2010年福建省肠道病毒71型分离株的基因型特征研究[J].中国人兽共患病学报,2012,28(1):6-9,13,5.基金项目
"十一五"国家科技重大专项"艾滋病和病毒性肝炎等重大传染病防治"(2009ZX10004-106) （2009ZX10004-106）
