中国人兽共患病学报2012，Vol.28Issue(1)：10-13,4.
福建省鼠伤寒沙门菌PFGE分子分型和耐药的关联性研究
Association between PFGE molecular typing and drug resistance of Salmonella typhimurium in Fujian
摘要
Abstract
To study the association between PFGE molecular typing and drug resistance of Salmonella typhimurium in Fujian, we carried out PFGE experiment and susceptibility test within 66 strains of S. typhimuriumn, and conducted association analysis. The 66 S. typhimurium were divided into 32 PFGE types. A 40. 9% (27/66) of them were P1, and 10. 6% (7/ 66)were P8, there were 51. 52%(34/66)strains classified into P1 and P8. Which were the prevalent types. In the drug resistance test, antibiotics were divided into 4 groups with cluster analysis, in which, cephalosporin and ciprofloxacin (quinolone ) were hypersensitive, and the sensitive rates were 94. 42% (61/66)and 62. 12%(41/66) respectively;P1 was the prevalent type in multidrug resistant strains (more than 6 resistant), amounting for 56. 82% of the total. The distribution of P1 had statistical significance between the group "more than 6 strains resistance" and the group "less than 6 strains resistance", while the distribution of P8 had no statistical significance between these two groups. Therefore, P1 and P8 were the prevalent gene types, and there was relationship between P1 and multidrug resistant strains (more than 6 strains resistance). At present, cephalosporin and ciprofloxacin (quinolone) are still the main antibiotics to treat Salmonella typhimurium in Fujian.关键词
鼠伤寒沙门菌/脉冲场凝胶电泳/分子分型/耐药性/关联性Key words
Salmonella typhimurium / PFGE/ molecular typing/ drug resistance/ association分类
医药卫生引用本文复制引用
杨劲松,陈建辉,林杰,郑金凤,严延生,陈爱平..福建省鼠伤寒沙门菌PFGE分子分型和耐药的关联性研究[J].中国人兽共患病学报,2012,28(1):10-13,4.基金项目
国家科技重大专项"传染病监测技术平台"项目(2009ZX10004-210) （2009ZX10004-210）
福建省卫生厅青年基金课题资助计划(No.2010-1-23) （No.2010-1-23）
