首页|期刊导航|中国神经再生研究（英文版）|Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush
中国神经再生研究（英文版）2012，Vol.7Issue(4)：295-301,7.DOI:10.3969/j.issn.1673-5374.2012.04.010
Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush
Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush
摘要
Abstract
In this study, we established a rat model of optic nerve crush to explore the effects of erythropoietin on retinal ganglion cell axonal regeneration. At 15 days after injury in erythropoietin treated rats, retinal ganglion cell densities in regions corresponding to the 1/6, 3/6 and 5/6 ratios of the retinal radius were significantly increased. In addition, the number of growth associated protein-43 positive axons was significantly increased at different distances (50, 250 and 500 μm) from the crush site after erythropoietin treatment. Erythropoietin significantly increased growth associated protein-43 protein levels in the retina after crush injury, as determined by western blot and immunofluorescence analysis. These results demonstrate that erythropoietin protects injured retinal ganglion cells and promotes axonal regeneration.关键词
erythropoietin/retinal ganglion cells/axonal regeneration/optic nerve crush/neural regenerationKey words
erythropoietin/retinal ganglion cells/axonal regeneration/optic nerve crush/neural regeneration引用本文复制引用
Haibo Tan,Xin Kang,Yisheng Zhong,Xi Shen,Yu Cheng,Qin Jiao,Lianfu Deng..Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush[J].中国神经再生研究（英文版）,2012,7(4):295-301,7.基金项目
This study was supported by the National Natural Science Foundation of China,No.81070728. （）
