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Detrimental impact of hyperlipidemia on the peripheral nervous system A novel target of medical epidemiological and fundamental research study

Song Wu Xu Cao Rongzhen He Kun Xiong

中国神经再生研究（英文版）2012，Vol.7Issue(5)：392-399,8.

中国神经再生研究（英文版）2012，Vol.7Issue(5)：392-399,8.DOI:10.3969/j.issn.1673-5374.2012.05.011

Detrimental impact of hyperlipidemia on the peripheral nervous system A novel target of medical epidemiological and fundamental research study

Song Wu ¹Xu Cao ²Rongzhen He ¹Kun Xiong³

作者信息

1. Department of Orthopedics, Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
2. Clinical Medicine Eight-year Program, 01 Class, 07 Grade, Central South University, Changsha 410013, Hunan Province, China
3. Department of Anatomy and Neurobiology, Xiangya Medical School of Central South University, Changsha 410013, Hunan Province, China
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摘要

Abstract

Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve system lesions and sympathetic nerve system dysfunction. Moreover, different lipid components such as cholesterol, triacylglycerols and lipoprotein are involved in the pathogenesis of these neuropathies. This review aimed to discuss the effect of hyperlipidemia on the peripheral nervous system and its association with peripheral neuropathies. Furthermore, a detailed discussion focusing on the explicit mechanisms related to hyperlipidemia-induced peripheral neuropathies is presented here. These mechanisms, including intracellular oxidative stress, inflammatory lesions, ischemia and dysregulation of local lipid metabolism, share pathways and interact mutually. In addition, we examined current information on clinical trials to prevent and treat peripheral neuropathies caused by hyperlipidemia, with a predictive discussion regarding the orientation of future investigations.

关键词

hyperlipidemia/peripheral nervous system/neuropathy/reviews

Key words

hyperlipidemia/peripheral nervous system/neuropathy/reviews

引用本文复制引用

Song Wu,Xu Cao,Rongzhen He,Kun Xiong..Detrimental impact of hyperlipidemia on the peripheral nervous system A novel target of medical epidemiological and fundamental research study[J].中国神经再生研究（英文版）,2012,7(5):392-399,8.

基金项目

The study was supported by the National Natural Science Foundation of China,No.81171461,30900773 （）

the Natural Science Foundation of Hunan Province,No.10JJ3038,11JJ2020 （）

"125 Tenant Project" of the Third Xiangya Hospital. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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