中国神经再生研究（英文版）2012，Vol.7Issue(6)：421-425,5.DOI:10.3969/j.issn.1673-5374.2012.06.003
Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats
Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats
Haiqin Wu 1Huqing Wang 1Bei Zhang 1Guilian Zhang 1Ru Zhang 1Lingfeng Zhang1
作者信息
- 1. Department of Neurology, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China
- 折叠
摘要
Abstract
In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha.关键词
puerarin/vascular dementia/hypoxia-inducible factor-1 alpha/erythropoietin/endothelial nitric-oxide synthaseKey words
puerarin/vascular dementia/hypoxia-inducible factor-1 alpha/erythropoietin/endothelial nitric-oxide synthase引用本文复制引用
Haiqin Wu,Huqing Wang,Bei Zhang,Guilian Zhang,Ru Zhang,Lingfeng Zhang..Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats[J].中国神经再生研究（英文版）,2012,7(6):421-425,5.
