首页|期刊导航|中国神经再生研究（英文版）|Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum
中国神经再生研究（英文版）2012，Vol.7Issue(6)：440-444,5.DOI:10.3969/j.issn.1673-5374.2012.06.006
Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum
Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum
摘要
Abstract
The present study collected cerebrospinal fluid samples from the corpus striatum in rats treated with borneol, moschus, storax, and acorus tatarinowii using brain microdialysis technology. Levels of excitatory neurotransmitters aspartic acid and glutamate, as well as inhibitory neurotransmitters glycine and ?-aminobutyric acid, were measured in samples using reversed-phase high-performance liquid chromatography, phosphate gradient elution, and fluorescence detection. Results showed that concentrations of all four amino acid neurotransmitters significantly increased in the corpus striatum following treatment with borneol or moschus, but effects due to borneol were more significant than moschus. Acorus tatarinowii treatment increased ?-aminobutyric acid expression, but decreased glutamate concentrations. Storax increased aspartic acid concentrations and decreased glycine expression. Results demonstrated that borneol and moschus exhibited significant effects on con amino acid neurotransmitter expression; storax exhibited excitatory effects, and acorus tatarinowii resulted in inhibitory effects.关键词
acorus tatarinowii/amino acid/borneol/microdialysis/high-performance liquid chromatography/moschus/neurotransmitter/resuscitation drugs/storaxKey words
acorus tatarinowii/amino acid/borneol/microdialysis/high-performance liquid chromatography/moschus/neurotransmitter/resuscitation drugs/storax引用本文复制引用
Na Zhang,Ping Liu,Xinrong He..Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum[J].中国神经再生研究（英文版）,2012,7(6):440-444,5.基金项目
The study was supported by the National Natural Science Foundation of China,No.81173572. （）
