首页|期刊导航|中国神经再生研究（英文版）|7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury
中国神经再生研究（英文版）2012，Vol.7Issue(6)：445-450,6.DOI:10.3969/j.issn.1673-5374.2012.06.007
7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury
7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury
摘要
Abstract
In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.关键词
7, 8-dihydroxycoumarin/growth associated protein 43/sciatic nerve/peripheral nerve injury/neural regenerationKey words
7, 8-dihydroxycoumarin/growth associated protein 43/sciatic nerve/peripheral nerve injury/neural regeneration引用本文复制引用
Jianshi Du,Qing Zhao,Yingli Zhang,Yu Wang,Ming Ma..7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury[J].中国神经再生研究（英文版）,2012,7(6):445-450,6.基金项目
This study was supported by the Science and Technology Development Foundation of Jilin Province,No.20100751 （）
a grant from Jilin Province Science and TechnologyDivision,No.200505174. （）
