首页|期刊导航|中国神经再生研究（英文版）|The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness
中国神经再生研究（英文版）2012，Vol.7Issue(7)：492-495,4.DOI:10.3969/j.issn.1673-5374.2012.07.002
The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness
The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness
摘要
Abstract
General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling.The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness.The general anesthetics sevoflurane and propofol were used.Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex (P < 0.05), but prolonged the time to recovery of the reflex (P < 0.05).Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane.These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.关键词
gap junction/blocker/propofol/sevoflurane/general anesthesia/nerve block/neuropharmacologyKey words
gap junction/blocker/propofol/sevoflurane/general anesthesia/nerve block/neuropharmacology引用本文复制引用
Zhigang Liu,Yongfang Liu,Bo Zhao,Li Du,Zhongyuan Xia,Xiangdong Chen,Tao Luo..The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness[J].中国神经再生研究（英文版）,2012,7(7):492-495,4.基金项目
This study was supported by the Natural Science Foundation of Hubei Province,No.2010CHB01001. （）
