中国神经再生研究（英文版）2012，Vol.7Issue(7)：496-500,5.DOI:10.3969/j.issn.1673-5374.2012.07.003
Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force microscopy
Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force microscopy
Jing Chen 1Hu Hao 2Guoqing Guo 3Sitao Li 2Xin Xiao2
作者信息
- 1. Institute of Gastroenterology, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
- 2. Laboratory of Inborn Errors of Metabolism, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
- 3. Department of Anatomy, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China
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摘要
Abstract
Hippocampal neurons of neonatal rats were cultured in serum-free culture medium for 5 days in vitro, and treated with the Rho-kinase inducer lysophosphatidic acid.Atomic force microscopy revealed that the numbers of level-1, -2 and -3 neurites protruding from rat hippocampal neurons was significantly reduced.After treatment with the Rho kinase inhibitor Y27632, a significant increase in the numbers of these neurites was observed.Our experimental findings indicate that the Rho-kinase pathway is closely associated with the neurites of hippocampal neurons.关键词
atomic force microscopy/Rho-kinase/nerve cells/neurites/hippocampus/rats/neural regenerationKey words
atomic force microscopy/Rho-kinase/nerve cells/neurites/hippocampus/rats/neural regeneration引用本文复制引用
Jing Chen,Hu Hao,Guoqing Guo,Sitao Li,Xin Xiao..Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force microscopy[J].中国神经再生研究（英文版）,2012,7(7):496-500,5.
