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Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats

Hua Li Changqi Li Ruping Dai Xudan Shi Junmei Xu Jianyi Zhang Xinfu Zhou Zhiyuan Li Xuegang Luo

中国神经再生研究（英文版）2012，Vol.7Issue(7)：517-522,6.
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中国神经再生研究（英文版）2012，Vol.7Issue(7)：517-522,6.DOI:10.3969/j.issn.1673-5374.2012.07.007

Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats

Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats

Hua Li 1Changqi Li 2Ruping Dai 3Xudan Shi 4Junmei Xu 4Jianyi Zhang 4Xinfu Zhou 3Zhiyuan Li 5Xuegang Luo3

作者信息

  • 1. Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province,China
  • 2. Department of Histology and Embryology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
  • 3. Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province, China
  • 4. Department of Anesthesia, Second Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
  • 5. Department of Human Physiology, Flinders University, South Australia, Australia
  • 折叠

摘要

Abstract

In this study, a rat model of inflammatory pain was produced by injecting complete Freund's adjuvant into the hind paw, and the expression of acetylated histone 3 in the spinal cord dorsal horn was examined using immunohistochemical staining.One day following injection, there was a dramatic decrease in acetylated histone 3 expression in spinal cord dorsal horn neurons.However, on day 7, expression recovered in adjuvant-injected rats.While acetylated histone 3 labeling was present in dorsal horn neurons, it was more abundant in astrocytes and microglial cells.The recovery of acetylated histone 3 expression was associated with a shift in expression of the protein from neurons to glial cells.Morphine injection significantly upregulated the expression of acetylated histone 3 in spinal cord dorsal horn neurons and glial cells 1 day after injection, especially in astrocytes, preventing the transient downregulation.Our results indicate that inflammatory pain induces a transient downregulation of acetylated histone 3 in the spinal cord dorsal horn at an early stage following adjuvant injection, and that this effect can be reversed by morphine.Thus, the downregulation of acetylated histone 3 may be involved in the development of inflammatory pain.

关键词

inflammation/hyperalgesia/acetylated histone 3/spinal cord/morphine/neurobiology

Key words

inflammation/hyperalgesia/acetylated histone 3/spinal cord/morphine/neurobiology

引用本文复制引用

Hua Li,Changqi Li,Ruping Dai,Xudan Shi,Junmei Xu,Jianyi Zhang,Xinfu Zhou,Zhiyuan Li,Xuegang Luo..Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats[J].中国神经再生研究（英文版）,2012,7(7):517-522,6.

基金项目

This study was supported by the National Natural Science Foundation of China,No.81070897,81102726. （）

中国神经再生研究（英文版）

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