中国神经再生研究（英文版）2012，Vol.7Issue(8)：589-594,6.DOI:10.3969/j.issn.1673-5374.2012.08.005
Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage
Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage
Baixiang He 1Gang Bao 1Shiwen Guo 1Gaofeng Xu 1Qi Li 1Ning Wang1
作者信息
- 1. Department of Neurosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
- 折叠
摘要
Abstract
Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flow cytometry and immunohistochemical staining of the p75 neurotrophin receptor. p75 neurotrophin receptor protein was detected by immunohistochemistry. p75 neurotrophin receptor mRNA was examined by quantitative real-time polymerase chain reactions. At 24 hours after modeling, cellular apoptosis occured around hematoma with upregulation of p75 neurotrophin receptor protein and mRNA was observed, which directly correlated to apoptosis. This observation indicated that p75 neurotrophin receptor upregulation was associated with cell apoptosis around hematomas after intracerebral hemorrhage.关键词
intracerebral hemorrhage/apoptosis/p75 neurotrophin receptor/neural regenerationKey words
intracerebral hemorrhage/apoptosis/p75 neurotrophin receptor/neural regeneration引用本文复制引用
Baixiang He,Gang Bao,Shiwen Guo,Gaofeng Xu,Qi Li,Ning Wang..Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage[J].中国神经再生研究（英文版）,2012,7(8):589-594,6.
