中国神经再生研究（英文版）2012，Vol.7Issue(9)：659-663,5.DOI:10.3969/j.issn.1673-5374.2012.09.003
Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil
Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil
Ren'an Qin 1Desheng Zhou 2Jiajun Wang 2Hua Hu 2Yang Yang 2Xiaoxuan Yao 1Xiaopeng Sun2
作者信息
- 1. Modern Chinese Medicine Research Institute of Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, Guangdong Province, China
- 2. Department of Neurology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China
- 折叠
摘要
Abstract
After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer’s disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer’s disease, with similar effects to donepezil.关键词
amyloid protein precursor/Alzheimer's disease/transgenic cell model/compound Danshen tablets/Chinese medicine/neural regenerationKey words
amyloid protein precursor/Alzheimer's disease/transgenic cell model/compound Danshen tablets/Chinese medicine/neural regeneration引用本文复制引用
Ren'an Qin,Desheng Zhou,Jiajun Wang,Hua Hu,Yang Yang,Xiaoxuan Yao,Xiaopeng Sun..Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil [J].中国神经再生研究（英文版）,2012,7(9):659-663,5.
