中国比较医学杂志2011，Vol.21Issue(12)：38-41,4.DOI:10.3969/j.issn.1671-7856.2011.12.010
冠脉结扎和介入两种方法制备犬心肌梗死模型的比较
Comparison of Two Canine Models of Acute Myocardial Infarction Established by Coronary Artery Ligation and Coronary Embolism
刘素蕊 1赵春生 1王更银 1李振奇 1李俊峡1
作者信息
- 1. 解放军白求恩国际和平医院,石家庄050082
- 折叠
摘要
Abstract
Objective To observe the characteristics of coronary artery ligation and coronary embolism for preparation of acute myocardial infarction (AMI) models in canine. Methods The left main anterior descending coronary artery was obstructed by either open thoracotomy ligation or closed-chest coronary embolism. The electrocardiogram changes were recorded before and after blocking coronary blood flow. At 72 hours after the acute myocardium infarction model preparation, the dogs were sacrificed and specimens of the myocardium were taken for histopathological examination. Results Both electrocardiogram and histopathology confirmed that both methods could establish AMI models successfully. Compared with open-chest coronary artery ligation, the closed-chest coronary embolism had a higher survival rate. Conclusion Closed-chest coronary artery embolism deserves recommendation due to the advantages such as safety and convenience in the preparation of dog models of acute myocardial infarction.关键词
急性心肌梗死/模型/冠脉结扎/犬Key words
Acute myocardial infarction/ coronary artery ligation/ Model/ canine分类
医药卫生引用本文复制引用
刘素蕊,赵春生,王更银,李振奇,李俊峡..冠脉结扎和介入两种方法制备犬心肌梗死模型的比较[J].中国比较医学杂志,2011,21(12):38-41,4.
