中国比较医学杂志2011，Vol.21Issue(12)：46-50,5.DOI:10.3969/j.issn.1671.7856.2011.12.012
土茯苓对肾性高血压大鼠血压的调节作用和机制
Regulatory Effects and Mechanism of Smilax glabra on Blood Pressure in Renovascular Hypertensive Rats
摘要
Abstract
Objective To observe the regulatory effects of Smilax glabra on blood pressure and vasoactive substances in renovascular hypertensive rats. Method Seventy healthy adult male rats were used to establish the model of renovascular hypertension by two-kidney two-clip procedure. Model rats were divided into model control group, high (Smilax glabra 6 g/kg) , moderate (Smilax glabra 3 g/kg) , low (Smilax glabra 1. 5 g/kg) dose groups and the positive control group (captopril 5 mg/kg) according to systolic blood pressure in the renal hypertensive rats. Rats of the drug groups were administrated the corresponding drugs by once daily for 4 weeks, and measured blood pressure once a week. After the last administration, the blood ANP, NO, ET, CGRP and Ang II of the rats were measured. Result Smilax glabra significantly reduced SBP, DBP and MBP in the renal hypertensive rats ( P < 0. 05, P < 0. 01 ) , significantly reduced the ANP, ET levels ( P < 0. 05 , P < 0. 01) , and increased the NO level (P < 0. 05 ) . Conclusion Smilax glabra has a blood pressure lowering effect and regulates the blood pressure by reduced ANP, ET, and increased NO levels.关键词
土茯苓/肾性高血压大鼠/血压/血管活性物质Key words
Smilax glabra/ Renovascular hypertensive rat/ Blood pressure/ Vasoactive substances分类
医药卫生引用本文复制引用
王德军,张利棕,方明笋,周卫民,寿旗扬,蒋剑平,蔡月琴,朱科燕,陈民利..土茯苓对肾性高血压大鼠血压的调节作用和机制[J].中国比较医学杂志,2011,21(12):46-50,5.基金项目
浙江省高校科研计划项目(Y200909174) （Y200909174）
2.受"浙江省卫生高层次创新人才培养工程项目"资助. （）
