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Cramp过表达对小鼠骨髓造血干细胞功能的影响

石桂英 陈显达 陈陟阳 马小茗 鞠振宇

中国比较医学杂志2012,Vol.22Issue(1):13-17,5.
中国比较医学杂志2012,Vol.22Issue(1):13-17,5.DOI:10.3969/j.issn.1671.7856.2012.001.004

Cramp过表达对小鼠骨髓造血干细胞功能的影响

Influence of Cramp Over Expression on the Function of Hematopoietic Stem Cell

石桂英 1陈显达 1陈陟阳 1马小茗 1鞠振宇1

作者信息

  • 1. 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021
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摘要

Abstract

Objective to study the role of Cramp gene in the self-renew and differentiation of hematopoietic stem cells(HSCs). Methods cells from the bone marrow, spleen and thymus were analyzed by flow cytometry. HSCs were sorted and cultured in vitro. Results Compared with wild type mice, there are no great differences in the cell percentage and function of bone marrow, spleen and thymus in Cramp over expression mice. Conclusions Compared with the wild type mice, there was no great difference in the HSCs* differentiation and single cell clone in Cramp over expression transgenic mice.

关键词

Cramp过表达/转基因小鼠/骨髓造血干细胞

Key words

Cramp over expression/ Transgenic mouse/ Hematopoietic stem cells

分类

医药卫生

引用本文复制引用

石桂英,陈显达,陈陟阳,马小茗,鞠振宇..Cramp过表达对小鼠骨髓造血干细胞功能的影响[J].中国比较医学杂志,2012,22(1):13-17,5.

基金项目

中央级公益性科研院所基本科研业务费[ DWS201010 ]. ()

中国比较医学杂志

OACSTPCD

1671-7856

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