中国比较医学杂志2012，Vol.22Issue(1)：22-27,6.DOI:10.3969/j.issn.1671.7856.2012.001.006
不同周龄SD大鼠脏器重量及其化趋势分析
Analysis on Organ Weights and Their Changes Trend in Sprague Dawley Rats with Different Ages
摘要
Abstract
Objective To analyzing organ weights and their changes trend of SD rats with different ages and to provide theoretical reference for evaluating drug toxicity effect. Methods Weights data of brain, spleen, heart, lungs, liver, kidneys, adrenal glands, testis and ovaries from control group SD rats with 13 weeks, 26 weeks, 52 weeks, 78 weeks and 104 weeks ages was obtained. These weights data and their coefficients were analyzed. Results Weights of brain, spleen, heart, lungs, liver, kidneys, adrenal glands and ovaries were increased in female rats from 13 to 104 weeks. Weights of brain, spleen, heart, lungs, liver and kidneys of male rats were higher than that of female rats, whereas adrenal weights, its organ weight /body weight ratio and organ weight/ body weight ratio were significantly higher than that of males from 13 to 104 weeks. Conclusions This study firstly established different week ~ old SD rats organ weight background data and their reference range which in line with experimental animal status in our country and summarized their changes trend.关键词
SD大鼠/脏器重量/参考范围/脏器系数Key words
SD rat/ Organ weight/ Reference range/ Organ coefficient分类
医药卫生引用本文复制引用
柳云恩,姚宝玉,杨冬华,王捷..不同周龄SD大鼠脏器重量及其化趋势分析[J].中国比较医学杂志,2012,22(1):22-27,6.基金项目
国家"十一五"重大新药创制资助(2008 ZX09305-001). （2008 ZX09305-001）
