中国实用妇科与产科杂志2011，Vol.27Issue(12)：928-930,3.
抗β2糖蛋白Ⅰ抗体对抗磷脂综合征患者妊娠丢失及免疫调节治疗疗效影响
The influences of anti-β2-glycoprotein Ⅰ antibodies on pregnancy loss and therapeutic reaction of patients with APS
李娜 1朱付凡 1熊晶 1何凌 1吴静 1皮丕湘1
作者信息
- 1. 中南大学湘雅二医院妇产科,湖南长沙410011
- 折叠
摘要
Abstract
Objective To study the influences of anti-(32-glycoprotein I antibodies on pregnancy loss and therapy response of patients with APS. Methods 191 patients with APS were divided into 3 groups according to different antibodies detected, group A:ACA(+)B2GPI (-)(n = 154); group B:ACA(+)B2GP I (+)(n=26); group C:ACA(-) B2GP I(+)(n = ll). Analyze the pregnancy rate and therapeutic reaction of the patients. Results The pregnancy loss rate of group A,B and C before therapy were respectively 61. 59% ,69. 84% and 67. 86% .which were equal among the three groups. The pregnancy loss rate of group A, B and C after therapy were respectively 22.08% ,46. 15% , 36. 36% , which was lower in group A than group B (P < 0. 05) , and equal between group A and C, group B and C. Conclusion The influence of anti-β2-glycoprotein I antibodies on pregnancy loss rate was equal to ACA. Patients of APS who had both positive anti-β2-glycoprotein I antibodies and ACA were poorly reactive to immunoregulatory therapy.关键词
抗磷脂综合征/妊娠丢失/抗β2糖蛋白Ⅰ抗体/抗心磷脂抗体Key words
antiphospholipid syndrome/ pregnancy loss/ anti-B2-glycoprotein 1 antibodies/ anticardiolipin antibodies分类
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李娜,朱付凡,熊晶,何凌,吴静,皮丕湘..抗β2糖蛋白Ⅰ抗体对抗磷脂综合征患者妊娠丢失及免疫调节治疗疗效影响[J].中国实用妇科与产科杂志,2011,27(12):928-930,3.
