中国实用妇科与产科杂志2012，Vol.28Issue(1)：44-46,3.
宫颈鳞状上皮细胞癌组织中钙激活性中电导钾离子通道蛋白产物表达分析
The expression of intermediate-conductance-Ca2 + -activated K + channels protein in the tissues of cervical cancer
摘要
Abstract
Objective Comparing the intermediate-conductance-Ca2 + -activated K + channels (IKCal) protein in the tissues of cervical cancer with the normal tissue by the immuno-histochemical method. Methods The immuno-histochemi-cal method was used to examine the IKCal protein in the 18 cases of normal cervical tissue and 30 cases of different differentiation of cancer cells, all of the tissues came from the patients in the Affiliated Hospital of Luzhou Medical College between oct. 2007 and Apr. 2008. Results All the specimens of cervical cancer were expressing the IKCal protein in the nucleus, the positive rate was 100. 0% ; there was only 1 case expressing the IKCal antibody in the normal cervix, the positive rate was 5. 6%. The expression rate of IKCal protein in cervical cancer was higher than in normal cervix (Z = -6. 109, P = 0.00, P < 0.05 ). The highly differentiated cervical cancer' s positive rate was 40. 0% , the moderately differentiated cervical cancers positive rate was 90. 0% , the poorly differentiated cervical cancers positive rate was 100. 0%. The levels of IKCal protein in the cervical cancer were related in the degrees of differentiation of the cancer cells (χ2 = 8.4,P <0. 05). Conclusion There are higher expressions of IKCal protein in the cervical cancer than in the normal cervix. The relationship between the degrees of differentiation of cervical cancer cells and the expressions of IKCal protein is negative correlation. The over-expression of IKCal should be related with the occurrence and development of cervical cancer.关键词
钙激活性中电导钾离子通道/宫颈肿瘤/免疫组织化学Key words
IKCal/ cervical cancer/ immuno-histochemistry分类
医药卫生引用本文复制引用
林海蕤,毛熙光,傅晓冬,黄桂英,鲁照明..宫颈鳞状上皮细胞癌组织中钙激活性中电导钾离子通道蛋白产物表达分析[J].中国实用妇科与产科杂志,2012,28(1):44-46,3.基金项目
四川省科技厅项目(2008JY0014-1) （2008JY0014-1）
