中国兽医科学2011，Vol.41Issue(9)：950-953,4.
二甲苯对小鼠卵巢组织损伤的研究
Damage in ovary tissue of mouse exposed to xylene
摘要
Abstract
In order to study the damage of xylene to the ovary tissue of mouse,healthy adult female SD mice were randomly divided into 3（high,middle,low dose） experimental groups and one control group.The mice in experimental groups were injected different volume of xylene（0.5,0.25,0.125 mL/kg） and the mice in the control group were injected intraperitoneally with normal saline solution every day.Histological structure of murine ovary under different xylene volume were observed by HE staining and paraffin section.The activity of superoxide dismutase（SOD） and content of malondialdehyde（MDA） in the xylene-infected mouse ovary were measured by spectrophotometric method.Results showed that the xylene may lead to ovary atrophy and black solid grains were found in follicle in the middle and high dose group,and pathological changes of ovarian tissue was more obvious with xylene dose increasing.SOD activity were decreased significantly,while the content of MDA was significantly increased in high-and middle-dose groups compared with that of control group.It indicated that xylene may damage the ovary tissue of mice,and showed significant dose effect.关键词
二甲苯/小鼠/卵巢/超氧化物歧化酶/丙二醛Key words
xylene/mouse/ovary/SOD/MDA分类
农业科技引用本文复制引用
位兰,罗来强,张自强,李梦云,司立芳,李健,薛帮群..二甲苯对小鼠卵巢组织损伤的研究[J].中国兽医科学,2011,41(9):950-953,4.基金项目
河南科技大学博士科研启动基金项目（09001366) （）
