中国兽医科学2011，Vol.41Issue(10)：1076-1079,4.
阿散酸在猪体内的药动学与生物利用度研究
Study on pharmacokinetics and bioavailability of arsanilic acid in pigs
摘要
Abstract
Eight healthy crossed-bred（Yorkshire×Landrance）pigs,with an average weight of 25.0kg,were randomly assigned to two dietary treatments,and a randomized two period cross-over design was performed for single intravenous（i.v.） and oral administration of arsanilic acid（ASA）at the dose of 10.0mg/kg.Blood was taken in different preset times following drug administration and the concentrations of arsanilic acid in plasma were determined by HPLC using an ultraviolet detector.The concentrations versus time were analyzed with the moncompartmental approach based on statistical moment theory.In results,the main pharmacokinetics parameters of arsanilic acid in pigs after i.v.administration were as follows：β=0.55h-1±0.01h-1,t1/2β=1.26h±0.03h,Vz=0.30L/kg±0.01L/kg,Vdss=0.29L/kg±0.01L/kg,CL=0.17L/（kg·h）±0.01L/（kg·h）,MRT=1.75h±0.07h,AUC= 60.44μg/mL·h±0.01μg/mL·h.The main pharmacokinetics parameters after oral dosing of arsanilic acid in pigs,were as follows：β=0.39h-1 ±0.02h-1,t1/2β =1.79h±0.09h,tmax=1.81h±0.09h,Cmax=3.43μg/mL± 0.53μg/mL,MRT=3.95h±0.13h,AUC=15.12μg /mL·h±0.01μg /mL·h,F=24.5%±3.4%.In conclusion,arsanilic acid was absorbed quickly,and reached the tmax shortly with low Cmax and low bioavailability,and eliminated quickly after oral administration in pigs.关键词
阿散酸/猪/药动学/生物利用度Key words
arsanilic acid（ASA）/pigs/pharmacokinetics/bioavailability分类
农业科技引用本文复制引用
罗雪莲,李轲,陈超,白玲,张草,孙永学..阿散酸在猪体内的药动学与生物利用度研究[J].中国兽医科学,2011,41(10):1076-1079,4.基金项目
公益性行业（农业)科研专项（200903055) （）
