中国实用内科杂志2011，Vol.31Issue(12)：934-937,4.
上海宝钢职工非酒精性脂肪性肝病消退率及其影响因素研究
The remission rate and influence factors of non-alcoholic fatty liver disease in a cohort study of Shanghai Baosteel employees
摘要
Abstract
Objective To investigate the remission rate and influence factors of non-alcoholic fatty liver disease ( NAFLD) in Shanghai Baosteel employees. Methods Subjects free of abnormal aminotransferase and negative for hepatitis B virus surface antigen with alcohol consumption of less than 140 g/week were identified from employees of Shanghai Baosteel who underwent voluntary medical checkups at a 2-year interval between 1999 and 2001. Results The analyzed population consisted of 440 patients with NAFLD at baseline and 4867 subjects without fatty liver both at baseline and at the end of follow-up (group without fatty liver). Among NAFLD patients at baseline,60 subjects (13.6%) were found to have no fatty liver (group with remission of fatty liver) and the others (380 subjects) still had fatty liver (group without remission of fatty liver) at the end of follow-up. The remission rate of fatty liver in women younger than 50 years old (33. 3% ,3/9) was higher than in women 50 years old and over (4. 3% ,l/46)(χ2 =4. 969,P <0. 01). The remission rate of fatty liver in patients with NAFLD decreased gradually with increased body mass index (BMI) at baseline, dropping from 18. 2% in subjects with normal weight, 16. 5% in overweight patients, 13. 5% in obese patients to 7.8% in patients with severe obesity.There was a significant difference in the changes of BMI between 2001 and 1999 among group with remission of fatty liver( - 0. 26 ±1.18), group without remission of fatty liver ( 0. 39 ±1.13) and group without fatty liver (0. 50 ±1. 29) (F = 11.41,P<0. 01). This was also was true of the changes of serum triglyceride among group with remission of fatty liver [ ( - 0. 27 ± 0. 79 ) mmol/L ] , group without remission of fatty liver [ ( 0. 24 ± 1.88) mmol/L] , and group without fatty liver [(0. 11 ±1.07) mmol/L, F = 5. 58 , P < 0. 01 ]. Logistic regression analyses showed that the remission rate of fatty liver was correlated to BMI and serum triglyceride level at baseline and their changes during follow-up. Conclusion The remission rate of NAFLD is relative low. Its independent influencing factors include BMI and serum triglyceride at baseline as well as their changes.关键词
脂肪肝,非酒精性/消退率/肥胖症/体重指数/代谢综合征Key words
fatty liver, non-alcoholic/ remission rate/ obesity/ body mass index/ metabolic syndrome分类
医药卫生引用本文复制引用
周琦,范建高,陈源文,陈光瑜,沃千红..上海宝钢职工非酒精性脂肪性肝病消退率及其影响因素研究[J].中国实用内科杂志,2011,31(12):934-937,4.基金项目
上海市科委重点科技攻关项目(10411956300) （10411956300）
国家自然科学基金面上项目(81070322) （81070322）
国家科技部973项目课题(2012CB517501) （2012CB517501）
