中国实用外科杂志2011，Vol.31Issue(12)：1124-1126,3.
表面增强激光解吸电离飞行时间质谱筛查大肠癌早期肝转移病人血清特异性蛋白的探讨
Study of searching for the serum proteomic patterns of early liver metastasis of colorectal cancer by SELDITOF-MS
蔡相军 1王福荣 1王春喜 2王斌 1刘洪涛 1刘彩刚 3冷晗1
作者信息
- 1. 中国人民解放军第202医院,辽宁沈阳 110003
- 2. 中国人民解放军总医院,北京 100853
- 3. 中国医科大学附属第一医院,辽宁沈阳 110001
- 折叠
摘要
Abstract
Objective To detect the serum proteomic patterns in early liver metastasis of colorectal cancer patients by surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI- TOF-MS). Methods The relative contents of serum proteins of 20 colorectal cancer patients and 20 early liver metastasis of colorectal cancer patients were detected by WCX2 chip and SELDI-TOF-MS between 2007 and 2009 in 202 Hospital of PLA. Results At the M/Z values range from 2000u to 30 OOOu, the contents of two proteins (3774u and 11 85 lu) had significant difference in the two groups. Conclusions SELDI-TOF-MS shows great potentiality for early liver metastasis of colorectal cancer in diagnosis and screening of tumor biomarkers, and deserves generalization.关键词
大肠肿瘤/弱阳离子蛋白质芯片/表面增强激光解吸电离飞行时间质谱Key words
colorectal cancer/ weak cation exchanger protein chip/surface enhanced laser desorption/ionization time of flight mass spectrometry分类
医药卫生引用本文复制引用
蔡相军,王福荣,王春喜,王斌,刘洪涛,刘彩刚,冷晗..表面增强激光解吸电离飞行时间质谱筛查大肠癌早期肝转移病人血清特异性蛋白的探讨[J].中国实用外科杂志,2011,31(12):1124-1126,3.
