中国畜牧兽医2011，Vol.38Issue(11)：47-50,4.
牛磺鹅去氧胆酸对热应激小鼠免疫功能的调节作用
The Regulating Effects of Taurochenodeoxycholic Acid on Immune Function in Heat-stressed Mice
摘要
Abstract
To investigate regulating effects of taurochenodeoxycholic acid (TCDCA) on immune function in mice under heat stress,50 Kunming mice were divided randomly into five groups: normal control group,heat stress group,TCDCA1 group (50 mg/kg),TCDCA2 group (100 mg/kg),and TCDCA3 group (200 mg/kg). The mice of normal control group were fed in the temperature of 22 ℃ ,and the mice of other groups were treated with temperature of 35. 5 ℃ ±0. 5 ℃ and 60% humidity for 7 days. The spleen index,the change of T cell subgroup and B lymphocyte of peripheral blood,the contents of intestinal sIgA and serum IgG in mice were measured. The results showed that spleen index in mice of heat stress group was significantly lowered compared to the normal control group(P<0. 05) ;the contents of blood serum IgG and Intestinal sIgA were significantly (P< 0. 05) higher;the percentage of CD8+ and CD19+ lymphocytes decreased significantly (P<0. 05) ,and the CD4+ /CD8+ value increased significantly (P<0. 05), which demonstrated that the immune functions of mice under heat stress falls into disorders. The results also indicated that TCDCA have no effects on spleen index in heat stress,TCDCA enhanced the percentage of CD8+ and CD19+ lymphocytes in peripheral blood remarkably (P<0. 05),TCDCA recovered the CD4+ /CD8+ value,remarkably and TCDCA decreased concentration of IgG in blood serum and sIgA in intestinal remarkably (P<0. 05). These findings suggested that the immunity of mice in heat-stress could be destroyed and leaded to disorder,and can be accumulated by TCDCA.关键词
牛磺鹅去氧胆酸/热应激/免疫调节Key words
taurochenodeoxycholic acid/ heat stress/immunological regulation分类
农业科技引用本文复制引用
夏俊峰,李金莲,李培锋,王丛丛,王振勇,石有斐..牛磺鹅去氧胆酸对热应激小鼠免疫功能的调节作用[J].中国畜牧兽医,2011,38(11):47-50,4.基金项目
国家自然科学基金项目(30800837). （30800837）
